The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicating relevant genetic research results to individual patients. An exploratory pharmacogenetic analysis was conducted in the international ovarian cancer phase III trial, AGO-OVAR 16, which found that patients with clinically important germ-line BRCA1/2 mutations had improved progression-free survival prognosis. Mechanisms to communicate BRCA results were evaluated, because these findings may be beneficial to (...) patients and their families. Communicating individual BRCA results was not anticipated during clinical trial design. Consequently, options were not available for patients to indicate their preference for receiving their individual results when they signed pharmacogenetic informed consent. Differences in local requirements, clinical practice, and opinion regarding the ethical aspects of how to convey genetic results to patients are all potential barriers to returning individual BRCA results to patients. Communicating the aggregate BRCA result from this study provided clinical investigators with a mechanism to disseminate the overall study finding to patients while taking individual circumstances, local guidelines and clinical practice into account. This study illustrates the importance of increasing the clarity and scope of informed consent and the need for patient engagement to ensure clinical trial participants can indicate their preference regarding receipt of potentially important individual pharmacogenetic results. This study was registered in the NCT Clinical Trial Registry under NCT00866697 on March 19, 2009, following approval from participating ethics committees. (shrink)

RESUMEN Nos adentramos en esos procesos de subjetivación en los que el músico de jazz experimenta en sí otras formas de corporalidad, que se dirimen entre sujeción a esquemas y ruptura de los corsés por una teatralidad en escena. Aparentemente, en la improvisación prima lo subversivo y la reificación del músico como autor libre; sin embargo, observamos empíricamente una corporalidad plural que trasciende el espacio de la escena y que facilita que todos los actores intervengan en el proceso de creación. (...) Hallamos una red de solidaridad que desplaza continuamente los puntos fijos por donde transita la música; así, cuando a un músico le falta el aire, su compañero le da el relevo. Si lo fundamental en la praxis de la música son las continuas alternativas que ofrece, concluimos con una reflexión ética sobre la naturaleza transitoria de la música y su temporalidad kairológica, en la que el músico, sintiendo la brevedad del instante de la nota que muere cuando nace, se reencuentra con lo insignificante de la que está hecha su condición humana. ABSTRACT We enter these processes of subjectivation in which the jazz musician experiences in himself other forms of corporeality, which are settled between subjection to schemes and breakup of the corsets by a theatricality on stage. Apparently, in improvisation what is subversive and the reification of the musician as a free author take priority; nevertheless, we empirically observe a plural corporeality that goes beyond the space of the scene and that facilitates that all the actors take part in the process of creation. We found a solidarity network that continuously displaces the fixed points where music circulates; thus, when a musician is short of breath, his partner takes over. If what is fundamental in the praxis of music is the continuous alternatives it offers, we conclude with an ethical reflection on the transitory nature of music and its kairological temporality, in which the musician, feeling the briefness of the instant of the note that dies when it is born, joins the insignificance of his human condition. (shrink)

RESUMEN Nos adentramos en esos procesos de subjetivación en los que el músico de jazz experimenta en sí otras formas de corporalidad, que se dirimen entre sujeción a esquemas y ruptura de los corsés por una teatralidad en escena. Aparentemente, en la improvisación prima lo subversivo y la reificación del músico como autor libre; sin embargo, observamos empíricamente una corporalidad plural que trasciende el espacio de la escena y que facilita que todos los actores intervengan en el proceso de creación. (...) Hallamos una red de solidaridad que desplaza continuamente los puntos fijos por donde transita la música; así, cuando a un músico le falta el aire, su compañero le da el relevo. Si lo fundamental en la praxis de la música son las continuas alternativas que ofrece, concluimos con una reflexión ética sobre la naturaleza transitoria de la música y su temporalidad kairológica, en la que el músico, sintiendo la brevedad del instante de la nota que muere cuando nace, se reencuentra con lo insignificante de la que está hecha su condición humana. ABSTRACT We enter these processes of subjectivation in which the jazz musician experiences in himself other forms of corporeality, which are settled between subjection to schemes and breakup of the corsets by a theatricality on stage. Apparently, in improvisation what is subversive and the reification of the musician as a free author take priority; nevertheless, we empirically observe a plural corporeality that goes beyond the space of the scene and that facilitates that all the actors take part in the process of creation. We found a solidarity network that continuously displaces the fixed points where music circulates; thus, when a musician is short of breath, his partner takes over. If what is fundamental in the praxis of music is the continuous alternatives it offers, we conclude with an ethical reflection on the transitory nature of music and its kairological temporality, in which the musician, feeling the briefness of the instant of the note that dies when it is born, joins the insignificance of his human condition. (shrink)

This volume has 41 chapters written to honor the 100th birthday of Mario Bunge. It celebrates the work of this influential Argentine/Canadian physicist and philosopher. Contributions show the value of Bunge’s science-informed philosophy and his systematic approach to philosophical problems. The chapters explore the exceptionally wide spectrum of Bunge’s contributions to: metaphysics, methodology and philosophy of science, philosophy of mathematics, philosophy of physics, philosophy of psychology, philosophy of social science, philosophy of biology, philosophy of technology, moral philosophy, social and political (...) philosophy, medical philosophy, and education. The contributors include scholars from 16 countries. Bunge combines ontological realism with epistemological fallibilism. He believes that science provides the best and most warranted knowledge of the natural and social world, and that such knowledge is the only sound basis for moral decision making and social and political reform. Bunge argues for the unity of knowledge. In his eyes, science and philosophy constitute a fruitful and necessary partnership. Readers will discover the wisdom of this approach and will gain insight into the utility of cross-disciplinary scholarship. This anthology will appeal to researchers, students, and teachers in philosophy of science, social science, and liberal education programmes. 1. Introduction Section I. An Academic Vocation Section II. Philosophy Section III. Physics and Philosophy of Physics Section IV. Cognitive Science and Philosophy of Mind Section V. Sociology and Social Theory Section VI. Ethics and Political Philosophy Section VII. Biology and Philosophy of Biology Section VIII. Mathematics Section IX. Education Section X. Varia Section XI. Bibliography. (shrink)

This article reconstructs Herbert Marcuse’s first and widely ignored philosophical project, as set out in his texts published from 1928 to 1933. In these texts, Marcuse tried to put in dialogue ideas from Heidegger and Marx to articulate a dialectic phenomenology of historical existence. This attempt, of great originality and philosophical ambition, was marked by tensions arising from the peculiar status given to the ontology of historicity in a framework of thought that maintained strong links with Marx. By analysing this (...) early philosophical project of one of the icons of the international student movement, theoretical tensions can be detected, which clarify the subsequent approach of this thinker as a member of the so-called Frankfurt School. (shrink)

Introduction: Resilience is a multidimensional and dynamic construct associated with positive growth and the capacity to transform stressful and negative factors into opportunities of personal development and self-improvement when faced with difficult experiences. The resilience process of each individual integrates multiple analysis levels, which range from genetic-environmental interactions to a complex process of adaptation between the individual and his/her family, friends, co-workers, society, and culture.Objective: To determine whether resilience improves in students of occupational therapy when exposed for the first time (...) to practice placement education.Methodology: Quasi-experimental, prospective, observational, multi-center study with a sample composed of students from the Degree of Occupational Therapy of the public universities of Málaga and Castilla-La Mancha. Two weeks prior to the beginning of the practice education period, the participants completed a questionnaire that included sociodemographic data and the area of their internships. They were also given the Spanish version of the Connor-Davidson's resilience scale. All these instruments were also completed 1 week after the end of the clinical practice.Results: There were statistically significant differences between the variables that make up resilience and the different internship areas. On the other hand, there was a significant improvement of global resilience after the clinical practice period, in both women and men, when the internship area was not considered.Conclusions: The results show that resilient students are more optimistic and work to improve a situation beyond doing simply what is expected of them, knowing how to control their feelings. This is beneficial for students in practice education, since, during these, they face difficult situations that require a resilient pattern, which helps reduce stress and the burnout syndrome. (shrink)

The term sustainability has become one of the most significant in the current era. It seems to be ubiquitous amongst academics, politicians, business leaders, media personnel and even the general public. It is no exaggeration to state that it is considered all over the world to be the most pressing issue to be addressed for the long-term future of the planet and its inhabitants. The topic is of course complex, and the issue of sustainability is under much debate as to (...) what it actually is and how it can be achieved, but it is completely certain that the resources of the planet are fixed in quantity and, once used, cannot be reused except through being reused in one form or another. At present, much of the discourse of sustainability has focused upon the environment and in particular upon climate change and the effects that this is having. Thus, the discourse has tended to be about mitigation. Sustainability of course requires all three pillars of the triple bottom line—economic, environmental and social—to be addressed. Indeed, it might be considered that the effects upon the social, and how we choose to live our lives, might well be the most profound effect of achieving sustainability. This book therefore focuses upon some of the many aspects of the social and how we can adapt our lives to accommodate the requirements of sustainability. it therefore takes a very different approach to addressing the issues of sustainability, while of course not ignoring the other pillars. This book therefore sets out to examine various aspects of the changes to personal, corporate and institutional behaviour which may have to come about in our search for sustainability. It is tended to address some of the issues and how they are being dealt with in various parts of the world. As always, our concept is to share best practice and thereby enrich both the discourse and our progress towards sustainability. Thus, we focus upon the current situation while also considering the extent to which the focus is changing so much that we need to think about new approaches to our understanding of behaviour and differing effects in practice. The international origins of the contributors to this book make this an original contribution taking some of the best ideas from around the world. This book therefore addresses these issues from a perspective not generally addressed by researchers, or even by politicians and the press. It therefore provides fresh perspectives upon the important issue of our common future. As always, this approach is based on the tradition of the Social Responsibility Research Network srrnet.org (a worldwide body of scholars with membership of several thousand), which in its 20-year history has sought to broaden the discourse and to treat all research as inter-related and relevant to business. This tradition has always been to explore the subject widely and to seek relevant solutions, while also sharing best practice. This book is based primarily upon some of the contributions from the network at our recent conference and shows both commonality and diversity in approaches and effects. (shrink)

There can be no doubt that discrimination based on sex, race, ethnicity, religion or beliefs should not be tolerated in academia. Surprisingly, however, in recent years, policies of Diversity, Inclusion and Equity(DIE), officially introduced to counteract discrimination, have increasingly led to quite the opposite result: the exclusion of individuals who do not share a radical 'woke' ideology on identity politics (feminism, other gender activisms, critical race theory, etc.), and to the suppression of the academic freedom to discuss such dogmas. This (...) subversion of academia ― disguised Trojan-horse style as universal human rights advocacy ― is unacceptable because academia must be politically neutral and protect freedom of speech, a cornerstone of professional scholarly activity without which universities as we know them will slowly but surely suffocate. -/- Our purpose here is to put together some particularly illustrative cases of such repression in a single book, testifying to a ubiquitous trend within western culture, irreducible to a few isolated complaints. The essays contained here illustrate the abuse of power, censorship and witch-hunts at many universities and research centres in the name of DIE. -/- List of coauthors in alphabetical order: Dorian Abbot, Tomonori Agoh, Gerhard Amendt, Ivar Arpi, David Benatar, Peter Boghossian, Civitas Research Team, David Díaz Pardo de Vera, Pedro Domingos, Janice Fiamengo, Étienne Forest, Jorge Gibert Galassi, Norman Goldstuck, José L. González Quirós, Lawrence M. Krauss, Patrick LaBelle, Martín López Corredoira, Heather Mac Donald, Martin Malmgren, Erik. J. Olsson, Jordan Peterson, Constantin Polychronakos, Philip C. Salzman, Alessandro Strumia, Tom Todd, Andrei Yafaev. (shrink)

Proponemos una teoría estética basada en un enhebrado cronotópico del discurso creativo que replantea las lógicas de constitución del sujeto. Tomamos como hilo conductor la película La voz de la luna (La voce della Luna, 1990) de Federico Fellini, cuyo surrealismo, lejos de suponer una construcción al azar de un relato, revela una sofisticada narrativa desde lo circunstancial (y no desde el sujeto o el objeto). Es aquí donde confluimos con las tesis más radicales de Antonin Artaud y su proyecto (...) político basado en el teatro de la crueldad y la reificación del fragmento-órgano. Concluimos con un alegato por una narración vital, que trascienda la obra, disipe la posición del sujeto en la misma (lo que Jacques Derrida denomina Forcener le subjectile) para que el sentido de la humanidad, en lo ínfimo y fragmentado, trasparezca. (shrink)

El presente artículo realiza un estudio de la recepción en España de la Teoría crítica de la Escuela de Fráncfort, desde la década de los 60 del siglo XX hasta la actualidad. La originalidad de este trabajo es su pretensión de analizar este proceso de recepción académica y cultural sobre el trasfondo de los grandes cambios políticos que afectaron al país en este periodo. Las modificaciones del contexto político han sido adoptadas aquí como una clave interpretativa adicional y complementaria a (...) las interpretaciones intra-teóricas para iluminar en su complejidad y en sus sorprendentes vaivenes la recepción de esa corriente de pensamiento en nuestro país. El resultado es una consideración historizadora de las fases de esta recepción que posibilita y pretende impulsar una reflexión crítica de los investigadores de este ámbito sobre su pasado y su presente. (shrink)

La estética posee una importancia central en el pensamiento de Nietzsche. En el presente trabajo se expone cómo la afirmación filosófica nietzscheana de lo inmanente tiene como sustento sus reflexiones en torno al arte y extrae de este ámbito su instrumental teórico. Se mostrará así cómo Nietzsche lleva a cabo una justificación estética de la inmanencia.

El presente artículo se confronta con una problemática que ha focalizado los debates teóricos en torno a los fundamentos normativos de la crítica en las últimas décadas. La cuestión es si, en un marco social escindido como el nuestro, la crítica tiene que asumir su carácter perspectivista, es decir, su estar ubicada en una de las perspectivas que se enfrentan en el escenario social. Si ello es así, el problema que se abre es el de la posibilidad o no de (...) legitimar racional, moral y políticamente una crítica que asume su estar ya siempre situada en uno de los horizontes normativos que coexisten en el marco social. Este trabajo afronta este problema poniendo en diálogo motivos de la hermenéutica y de la teoría crítica: con ello pretende realizar una aportación a lo que podríamos llamar una reflexión hermenéutica de la crítica, que logre articular carácter perspectivo y pretensión de normatividad de la misma. (shrink)

An important center in which genetic research started and was carried out in Brazil during the 20thcentury was situated at the Faculty of Philosophy, Sciences and Linguistics of the University of São Paulo, led by André Dreyfus (1897–1952). Beginning in 1943, the Ukrainian geneticist Theodosius Dobzhansky (1900–1975) visited Dreyfus’s group four times. This paper evaluates the impact of Dobzhansky’s visits on the studies of genetics and evolution developed by the members of Dreyfus’s group during the 1940s and the 1950s. The (...) study leads to the conclusion that Dobzhansky’s visits had an impact, not only in quantitative terms (the number of individual and joint publications), but also in qualitative terms. However, we also detect a decrease in the number of individual and joint publications related to the subject of the project during certain periods. The adoption of new experimental organisms by some members of the group; the involvement with subjects not related to the initial project, such as botany; Dobzhansky’s and his wife’s health problems during the third visit; and scientific disagreements between Dobzhansky and Brazilian researchers may have contributed to the decrease in publications. (shrink)

El presente libro recopila algunas de las mejores investigaciones presentadas en el “IX Coloquio Internacional de Estética y Arte” en La Habana en diciembre del 2015, redactadas ahora a modo de artículos. La estética y el arte a debate II está compuesto por 27 artículos y se encuentra dividido en cinco bloques que, de alguna manera, reflejan las temáticas centrales alrededor de las cuales giró el encuentro del 2015. Los bloques temáticos son: 1 Arte, estética y política, 2 Cine y (...) medios audiovisuales, 3 Nuevas prácticas artísticas, 4 Arte y cuerpo y 5 Miradas clásicas. (shrink)

Este artículo explora desde una perspectiva filosófica la forma como la rostricidad está asociada al deseo y producción de subjetividad. De ahí que el campo de interés se centre en cómo dichas categorías tensionan la constitución subjetiva de los sujetos, a tal punto que inciden en la proyección de su propio trayecto biográfico. Esto a partir de algunos planteamientos teóricos acuñados por filósofos como Foucault, Deleuze y Guattari, con respecto al papel del rostro como productor de significado cultural en la (...) gestión de la economía del deseo. Con miras a ambientar el texto, se tomará como recurso a Catarino, personaje de la novela Cien años de soledad, de Gabriel García Márquez. (shrink)

Paul de Man ha interpretado la teoría de la traducción de Walter Benjamín como precursora de las posiciones de la deconstrucción. Por el contrario, aquí se va a demostrar la centralidad del mesianismo en la teoría del lenguaje y de la traducción de Benjamín, así como en su posterior concepción materialista de la historia. Se va a mantener que la fuerza teórica del pensamiento de este autor tiene como base precisamente tal elemento teológico.

El presente artículo va a mostrar la manera en que Benjamin realiza una interpretación dialéctica de la cultura de masas y, en concreto, del cine. Primero se abordará la tesis de Benjamin de que en la sociedad industrial desarrollada se produce una crisis del aura y veremos qué consecuencias extrae de tal crisis para la labor artística. También nos ocuparemos del modo en que pone en relación las técnicas artísticas y las transformaciones históricas de la experiencia social. Todo esto nos (...) pondrá en condiciones de afrontar la cuestión nuclear de nuestro trabajo: el modo en que Benjamin interpreta el cine atendiendo a sus efectos para la experiencia del colectivo social. Para terminar, se mostrará cómo este tipo de interpretación de la cultura ha sido continuado de manera fructífera por el crítico cultural más relevante de nuestros días: F. Jameson. Palabras clave: interpretación; cultura; marxismo. (shrink)

Das Crises às possibilidades da Educação Superior no Brasil: uma leitura a partir de Hannah Arendt Resumo: O texto procura entender os pressupostos da educação superior no Brasil e faz considerações sobre seus limites e potencialidades à luz de Hannah Arendt. Segundo Hannah Arendt, a crise da educação remete-se a uma crise de estabilidade de todas as instituições políticas e sociais. E para o enfrentamento dessa crise, Hannah Arendt sugere reconsiderar a crise da modernidade para se repensar criticamente o papel (...) da educação no mundo contemporâneo. De fato, sua reflexão assevera que a educação está entre as atividades mais elementares e necessárias da sociedade humana, e, por isso, tem de ser continuamente repensada em função das transformações do mundo no qual nascem novos seres humanos. Hannah Arendt, questiona e faz pensar como que a crise da e na educação impede todo desenvolvimento de tarefas e dinâmicas que ajudem, especialmente aos estudantes (em qualquer área de conhecimento) a possuírem e produzirem um conhecimento que leve a um enfrentamento de situações críticas do quotidiano. Palavras-Chave: Hannah Arendt; Educação Superior; Crise na Educação; Cidadania; Direito Educacional. From Crises to Possibilities of Higher Education in Brazil: a Reading Based on Hannah Arendt Abstract: The text aims to understand assumptions of higher education in Brazil and makes considerations about limits and potentialities concerning those assumptions in the light of Hannah Arendt. According to Hannah Arendt, the crisis in education refers to a crisis of stability of all political and social institutions. And to envisage this crisis, Hannah Arendt suggests reconsidering the crisis of modernity to critically rethink the role of education in the contemporary world. In fact, her reflection asserts that education is among the most fundamental and necessary activities of human society, and, therefore, it must be continually rethought considering transformations in the world in which new human beings are born. Hannah Arendt, questions and makes us think about how the crisis of and in education prevents any development of tasks and dynamics that help, especially for students (in any area of knowledge) to possess and produce knowledge that leads to facing critical situations in the everyday. Keywords: Hannah Arendt; Higher Education; Crisis on Education; Citizenship; Educational Law. Des crises aux possibilités d e l’enseignement supérieur au Brésil : une lecture chez Hannah Arendt Résumé: Le texte a le but de comprendre les présupposés de l'enseignement supérieur au Brésil et fait des considérations sur ses limites et ses potentialités à la lumière d'Hannah Arendt. Selon Hannah Arendt, la crise de l'éducation renvoie à une crise de stabilité de toutes les institutions politiques et sociales. Et pour faire face à cette crise, Hannah Arendt propose de reconsidérer la crise de la modernité afin de repenser de manière critique le rôle de l'éducation dans le monde contemporain. En effet, sa réflexion affirme que l'éducation fait partie des activités les plus élémentaires et les plus nécessaires de la société humaine et qu'elle doit, donc, être continuellement repensée à la lumière des transformations du monde dans lesquelles de nouveaux êtres humains voient le jour. Hannah Arendt, interroge et fait réfléchir sur la façon dont la crise de et dans l'éducation empêche tout développement de tâches et de dynamiques qui aident, en particulier pour les étudiants (dans n'importe quel domaine de la connaissance) à posséder et produire des connaissances qui conduisent à faire face à des situations critiques dans le quotidien. Mots-Clés : Hannah Arendt; Enseignement supérieur; crise de l'éducation; citoyenneté; droit éducatif. Data de registro: 23/12/2021 Data de aceite: 15/03/2022. (shrink)

Pretendemos neste trabalho sustentar a ideia de que, seguindo um percurso que vai de Sein und Zeit aos textos mais tardios, a compreensão do pensar, especialmente tendo em conta a íntima relação desta compreensão com o conceito de existência, esteve caracterizada pela concepção de finitude. Assim, segundo esta hipótese, o pensamento da história do ser teria como meta revelar ao mesmo tempo o retraimento do ser que se opera por um pensar – chamemo-lo de “expropriador” – e a necessidade de (...) se inaugurar um novo pensar, que é o que estaria em jogo na viragem. Intuídos já em Sein und Zeit morte e finitude, firmar-se-iam como conceitos nucleares para a compreensão da importância, do alcance e da posteridade da filosofia heideggeriana. (shrink)

Los autores no han tenido inconveniente en que se hagan públicas unas cartas que se cruzaron en 2001 discutiendo sus posiciones filosóficas.

In this paper we shall prove that certain subvarieties of the variety of Salgebras (Heyting algebras with successor) has amalgamation. This result together with an appropriate version of Theorem 1 of [L. L. Maksimova, Craig’s theorem in superintuitionistic logics and amalgamable varieties of pseudo-boolean algebras, Algebra i Logika, 16(6):643-681, 1977] allows us to show interpolation in the calculus IPC S (n), associated with these varieties.We use that every algebra in any of the varieties of S-algebras studied in this work has (...) a canonical extension, to show completeness of the calculus IPC S (n) with respect to appropriate Kripke models. (shrink)